What do we know of the Indian and Brazilian strains of COVID? Experts fear “super mutation”

What do we know of the Indian and Brazilian strains of COVID? Experts fear “super mutation”

There are many thousands of different versions, or variants, of COVID-19 circulating.
This is because all viruses mutate as they make copies of themselves to spread and thrive.

Most of these differences are inconsequential. A few can even be harmful to the virus’s survival. But some can make it more infectious or threatening.

One of these more infectious strains is the Brazilian variant, which is clearly now circulating in Trinidad and Tobago.

Evidence suggests that this Brazilian variant, also known as P-1, can spread more easily than other currently circulating strains of COVID-19. There are also concerns that the mutated form of the virus will decrease the susceptibility of the virus to immunisation through vaccination or prior infection.

This means that if someone was previously infected with COVID-19, the immune system may not as effectively fight off a second infection with this variant.

The Brazil variant has more potentially important changes in the spike protein.
It has a key mutation, called E484K, that may help the virus evade parts of the immune system, called antibodies, that can fight coronavirus based on experience from prior infection or a vaccine.

Data from CARPHA suggests that the AstraZeneca vaccine is effective against the Brazilian strain.

Now, to the COVID-19 coronavirus currently ravaging India, which is dubbed B.1.617, or the India variant.
It is still unclear how dangerous it is.

The number of new coronavirus infections has continued to rise sharply in India. Health authorities recorded more than 320,000 new cases and a further 2,771 deaths in the past 24 hours among its total population of 1.38 billion people. Several countries, including Germany, have pledged assistance.

It’s too early to say whether the new variant of the virus, B.1.617, is responsible for the rapid increase in infections, but it is being treated as a possible cause.

What role do virus variants play?
In many other cases and countries, new variants have played a role when infections jumped.

Some experts are also concerned that the Indian variant may be turning into a type of “super mutation” that will continue to spread across the world.

Director-General of the World Health Organization (WHO) Tedros Adhanom Ghebreyesus has said that he is “deeply concerned” about the situation in India, the WHO tweeted.

And the Indian variant has spread to other countries. Health authorities have detected variant B.1.617 in Germany, Belgium, the United Kingdom, Switzerland, the United States, Australia and Singapore. The British health ministry has also reported several dozen cases.

Why could the Indian variant become dangerous?
The Indian variant consists of two mutations on the spike protein of the virus.

A spike protein allows a virus to enter the body and infect it. The virus can then spread quickly through the body, if it escapes any antibodies in the immune system or those developed as a result of a vaccine — or, indeed, if there aren’t any antibodies.

Experts say there is a risk that people who have recovered from a COVID-19 infection, or those who have been vaccinated, may not be as resilient against this new variant as they may be against other forms of the virus.

What’s special about the Indian variant?
The mutations found in the Indian variant are identified as E484Q and E484K.

They are not entirely new. They have also been identified in other mutations, such as the South African variant, B.1.353, and previously mentioned in this article, the Brazilian variant, P1.

In some cases, the Indian mutations were detected in the British variant, B.1.1.7.

Of interest or of concern?
The WHO categorizes the Indian variant as a “variant of interest.” That means it is being monitored, but that it is, for the time being, not of major concern.

Dr Jeffrey Barrett, director of the COVID-19 Genomics Initiative at the Wellcome Sanger Institute in the UK, has commented that the Indian variant has spread at such low levels over the past few months, and that makes it “likely not to be as transmissible as B.1.1.7.”

But a number of other experts see the threat differently. And current developments appear to suggest they may be right.

In the Indian state of Maharashtra, more than 60% of all coronavirus infections have been linked to the new B.1.617 variant, based on the infections that have been sequenced for their origin.

But local authorities say the number of cases being sequenced is far too low for them to draw any clear conclusions.

As such, it remains unclear whether the Indian variant is responsible for the increase in infections in India.

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